Recently, Professor Yin Xuebo from the School of Chemistry and Chemical Engineering guided Master's student Hu Mengzi to publish a research paper titled STING active immunomodulatory bio blue for multiple postsurgical management in the academic journal Journal of Controlled Release (Top of the First District of the Chinese Academy of Sciences, Impact Factor 10.5). Professor Yin Xuebo is the corresponding author, Hu Mengzi is the first author, Wang Yaqiong, an attending physician in the Radiology Department of Zhongshan Hospital affiliated with Fudan University, is the co first author and co corresponding author, and Shanghai University of Engineering and Technology is the first and corresponding unit.
In addition to the robust adhesive properties, there is a pressing demand for ideal adhesives in tumor surgery that possess anti-tumor therapeutic effects. In this study, we introduce BSA-MnO2-GP@Ca-Y (BMGY) bio-glue by integrating bovine serum albumin (BSA)-MnO2, genipin (GP), and Ca-Y zeolite. Ca-Y zeolite exhibits the thrombin activity for hemostasis, while the cross-linking of BSA, GP, and skin tissue induces wound adherence upon laser irradiation for normalized skin structure within nine days. The heat generated during the “photothermal suture” process ablates residual tumor cells and produces antigen fragments, which are internalized by antigen presenting cells. The released Mn ions subsequently activate the cGAS-STING pathway, enhancing immunogenicity. Consequently, tumor-infiltrating p-TBK1 and interferon-β levels are significantly increased, ensuring robust anti-tumor immunity following BMGY treatment. Thus, BMGY bio-glue achieves hemostasis, wound bonding, ablation of residual tumor cells, and tumor recurrence inhibition, simultaneously. Beyond Ca-Y zeolite, BSA-MnO2-GP serves as a versatile platform for loading other drugs or active species to boost therapeutic efficacy. Therefore, we present a successful bio-glue paradigm with significant translational potential for various postsurgical management applications.
This work was supported by the National Natural Science Foundation of China (Grant Nos. 22374096 and 22174077), Shanghai Sailing Program (Grant No. 23YF1441700).